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HelpTest Code FMSS2 Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A
Specimen Required
Specimen collection must occur between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for maternal serum screening is 16 to 18 weeks gestation. Acceptable date ranges to collect the second sample is provided in the Integrated-1 report.
Collection Container/Tube: Serum gel or red top
Submission Container/Tube: Plastic vial
Specimen Volume: 3 mL Serum
Collection Instructions:
1. As soon as possible or within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
2. Send refrigerate.
Note: This test requires that a previous first trimester specimen, FFMSS / Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT has been performed.
Method Name
Quantitative Chemiluminescent Immunoassay (CLIA)
Reporting Name
Maternal Serum Screen INT, Sp-2Specimen Type
SerumSpecimen Minimum Volume
Serum: 1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 365 days | |
| Ambient | 72 hours |
Reject Due To
| Hemolysis | Reject |
| Plasma | Reject |
Clinical Information
Refer to https://ltd.aruplab.com/
Reference Values
An interpretive report will be provided.
Interpretation
An interpretive report will be provided. Part 2 must be completed to receive an interpretable result. If the second specimen is not received for sequential screening, the results are uninterpretable and no maternal risk will be provided.
Cautions
A screen interpreted as "normal" misses approximately 15% of Down syndrome, 20% of open neural tube defects and 10% of trisomy 18 cases.
Abnormal results require follow-up with targeted ultrasound, genetic counseling, and consideration of fetal diagnostic testing.
Day(s) Performed
Monday through Sunday
Report Available
4 to 8 daysPerforming Laboratory
ARUP LaboratoriesCPT Code Information
81511
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FMSS2 | Maternal Serum Screen INT, Sp-2 | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z5170 | Patient's AFP | 1834-1 |
| Z5171 | MoM for AFP | 20450-3 |
| Z5172 | Patient's uE3 | 2250-9 |
| Z5173 | MoM for uE3 | 20466-9 |
| Z5174 | Patient's hCG, 2nd Trimester | 19080-1 |
| Z5175 | hCG MoM, 2nd Trimester | 20465-1 |
| Z5176 | Patient's DIA | 23883-2 |
| Z5177 | MoM for DIA | 35738-4 |
| Z5178 | PAPP-A Maternal | 32046-5 |
| Z5179 | MoM for PAPP-A | 32123-2 |
| Z5180 | Nuchal Translucency (NT) | 12146-7 |
| Z5181 | MoM for NT | 49035-9 |
| Z5182 | Nuchal Translucency (NT), Twin B | 12146-7 |
| Z5183 | MoM for NT, Twin B | 49035-9 |
| Z5184 | Maternal Screen Interpretation | 49586-1 |
| Z5185 | Maternal Age At Delivery | 21612-7 |
| Z5186 | Maternal Weight | 29463-7 |
| Z5187 | Estimated Due Date | 11778-8 |
| Z5188 | Gestational Age for Second Specimen | 18185-9 |
| Z5189 | Dating | 21299-3 |
| Z5190 | Number of Fetuses | 11878-6 |
| Z5191 | Maternal Race | 21484-1 |
| Z6445 | Maternal Diabetes at Conception | 44877-9 |
| Z5193 | Smoking | 64234-8 |
| Z5194 | Family Hx Neural Tube Defect | 8670-2 |
| Z5195 | Family History of Aneuploidy | 32435-0 |
| Z5196 | Specimen | 19151-0 |
| Z5197 | Crown Rump Length | 11957-8 |
| Z5198 | Crown Rump Length, Twin B | 11957-8 |
| Z5199 | Sonographer Certification Number | 49089-6 |
| Z5200 | Sonographer Name | 49088-8 |
| Z5201 | Ultrasound Date | 34970-4 |
| Z5202 | EER Maternal Serum, Integrated, Sp2 | 11526-1 |