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HelpTest Code LAB26 Creatinine Clearance, Plasma or Serum and Urine
Additional Codes
| Test Name in EPIC | EPIC Test Code | Mnemonic |
|---|---|---|
| CREATININE CLEARANCE | LAB26 | UCRCL |
Test Alias
CrCL
CRTCL
Creat Clear
Creatinine Clearance
Useful For/Utility
Estimation of glomerular filtration rate
Methodology
Kinetic Alkaline Picrate
Clinical Information
Use of an estimating or prediction equation to estimate GFR from serum creatinine should be employed for people with chronic kidney disease (CKD) and those with risk factors for CKD (diabetes, hypertension, cardiovascular disease, and family history of kidney disease). Reasons given for routine reporting of eGFR with every serum creatinine in adult (18 and over) patients include:
GFR and creatinine clearance are poorly inferred from serum creatinine alone. GFR and creatinine clearance are inversely and nonlinearly related to serum creatinine. The effects of age, sex, and, to a lesser extent, race, on creatinine production further cloud interpretation.
Creatinine is commonly measured in routine clinical practice. Albuminuria (>30 mg/24 hour or urine albumin to creatinine ratio >30 mg/g) may be a more sensitive marker of early renal disease, especially among patients with diabetic nephropathy. However, there is poor adherence to guidelines that suggest annual urinary albumin testing of patients with known diabetes. Therefore, if a depressed eGFR is calculated from a serum creatinine measurement, it may help providers recognize early CKD and pursue appropriate follow-up testing and therapeutic intervention.
Specimen Requirements
Plasma or serum and urine are required. Plasma or serum must be drawn within 72 hours of urine collection.
Plasma or Serum
Submit only 1 of the following specimens:
Preferred:
Specimen Type: Plasma
Container/Tube: Light-green top (lithium heparin gel)
Specimen Volume: 1 mL
Specimen Minimum Volume: 0.5 mL
Collection Instructions:
1. Separate plasma from cells within 2 hours of draw.
2. If plunger filters are used, immediate removal of plasma is indicated unless an air gap can be created between the device and specimen.
Additional Information:
1. Patient’s height and weight are required.
2. Label specimen appropriately (plasma).
Alternate:
Specimen Type: Serum
Container/Tube: Red top or serum gel
Specimen Volume: 1 mL
Specimen Minimum Volume: 0.5 mL
Collection Instructions:
1. Separate serum from cells within 2 hours of draw
2. If plunger filters are used, immediate removal of serum is indicated unless an air gap can be created between the device and specimen.
Additional Information:
1. Patient’s height and weight are required.
2. Label specimen appropriately (serum).
Specimen Type: Urine, 24-hour
Container/Tube: Aliquot
Specimen Volume: 5 mL
Specimen Minimum Volume: 2 mL
Collection Instructions:
1. No preservative.
2. Mix well before taking 5-mL aliquot.
Additional Information:
1. Patient’s height and weight, starting and ending times of collection, and 24-hour volume are required.
2. Provide patient with a Creatinine Clearance Patient Instruction Sheet.
3. Specimen containing 6N HCl or boric acid is acceptable.
4. See Urine Collection in Special Instructions for timed urine collection instructions.
Performing Laboratory
Measure 24-hour urine volume. Enter volume and hours of collection into LIS. Pour aliquot of urine into a smaller testing container. If specimen is cloudy, spin and separate supernatant. Refrigerate specimen until analysis is performed.
Specimen Transport Temperature
Plasma or Serum-Refrigerate 5 days/Ambient 8 hours OK/Frozen OK
Urine-Refrigerate 5 days/Frozen NO/Ambient NO
Day(s) Test Set Up
Monday through Sunday
Performing Laboratory
Chemistry -
St. Joseph's - Baxter Clinic Lab, St. Joseph's - Brainerd Clinic Lab, St. Joseph's Medical Center Lab
Ashland Clinic Lab, Deer River Hospital Lab, Ely Clinic Lab, Hayward Clinic Lab, Hibbing Clinic Lab, International Falls Clinic Lab, Moose Lake Hospital Lab, Northern Pines Lab, Sandstone Hospital Lab, SMDC Clinical Lab, Spooner Clinic Lab, St. Mary's Hospital - Superior Lab, Virginia Hospital Lab
Ada Hospital Lab, Fargo Hospital Lab, Fosston Hospital Lab, Park Rapids Clinic Lab, St. Mary's - Detroit Lakes Hospital Lab
Test Classification and CPT Coding
82565
Reference Values
Male: 75-135 mL/minute
Female: 70-130 mL/minute