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HelpTest Code LAB8032 Antibody Titer for Obstetrics
Additional Codes
| Test Name in EPIC | EPIC Test Code | Mnemonic |
|---|---|---|
| ANTIBODY TITER OB | LAB8032 | ABYTITER |
Test Alias
ANTIBODY TITR OB, Titer
Useful For/Utility
Titration studies are used to estimate antibody activity in alloimmunized pregnant women to determine whether and when to perform more complex invasive investigation of the fetal condition, such as amniotic fluid analysis, RUBS, or cerebral artery velocity. These procedures are used to determine the need for intrauterine transfusion or early delivery.
Methodology
Manual
This test determines the level of clinically significant antibody in a prenatal patient specimen.
Test Algorithm
Antibody titer will include antibody identification and appropriate red cell antigen typing(s) as required. All clinically significant abitodies identified in a prenatal patient will reflex to an antibody titer. The Kell antibody can supress production of RBCs in the fetus and severity of the caused anemia is not related to the titer. Special considerations should be taken with managment of Kell sensitized patients. M antibodies can be either IgG or IgM, but rarely cause HDFN. Anti-P1, -I, -Lea, and -Leb have not been reported to cause HDFN and no titer is needed. If the antibody is no longer reacting in gel, performance of an antibody titer is not indicated.
Clinical Information
Titration is a semiquantitative method used to determine the concentration of antibody in a serum sample or to compare the strength of antigen expression on different red cell samples.
Specimen Requirements
Specimen Type: Whole blood
Container/Tube: Pink Top(K2EDTA)-Lavender top (EDTA) is also acceptable.
Specimen Volume: 6 mL
Specimen Minimum Volume: 2 mL
Collection Instructions: Send specimen in original tube.
Specimen Transport Temperature
Ambient/Refrigerate OK/Frozen NO
Day(s) Test Set Up
Monday through Friday
Performing Laboratory
Essentia Health Laboratory-Transfusion Services
St. Joseph's Medical Center Lab
SMDC Clinical Lab
Test Classification and CPT Coding
86886