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Test Code LABBTKIARP BTK Inhibitor Aquired Resistance Panel

Important Note

This panel detects mutations in BTK and PLC-gamma-2 which are associated with acquired ibrutinib resistance in certain B-cell neoplasms. This panel is appropriate for patients with B-cell neoplasms who have relapsed and/or show acquired (secondary) resistance after an initial response to BTK (Bruton tyrosine kinase) inhibitors.

Additional Codes

Test Name Epic ID Mnemonic
BTK Inhibitor Aquired Resistance Panel LABBTKIARP BTKIARP

 

Methodology

Molecular

Concurrent bi-directional sequencing of hotpost regions in the BTK and PLC-gamma-2 genes. Analysis includes the BTK mutation C481S and surrounding regions corresponding to amino acids C464 to M509 and the following PLC-gamma-2 mutations and surrounding regions: R665W (W646 to S679), S707 (A681 to M743), and L845F (I839 to V860).

Specimen Requirements

Peripheral blood: 5 mL in EDTA tube.
Bone marrow: 2 mL in EDTA tube.
FFPE tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.

https://neogenomics.com/sites/default/files/Requisition/Neo-Hematopathology-Requisition.pdf

Specimen must arrive within 72 hours of collection.

 

Specimen Transport Temperature

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Performing Laboratory

NeoGenomics

Test Classification and CPT Coding

81479

Report Available

10 Days