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HelpTest Code LABFPAIG Plasminogen Activator Inhibitor-1, 4G/5G Genotyping (PAI-1 Polymorphism)
Additional Codes
| Test Name in EPIC | EPIC Test Code | Mnemonic | Mayo Test ID |
|---|---|---|---|
| PLASMINOGEN ACTIVATOR INHIBITOR-1, 4G/5G GENOTYPING | LABFPAIG | FPAIG | FPAIG |
Method Name
Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technologies.
Reporting Name
PAI-1 Gene PolymorphismSpecimen Type
Whole bloodSpecimen Required
Specimen Type: Whole Blood
Preferred: EDTA
Acceptable: ACD (Yellow top)
Specimen volume: 5 mL
Collection Instructions: Draw 5 mL whole blood in a lavender top (EDTA) or yellow top (ACD) tube. Send refrigerated.
Specimen Minimum Volume
1.00 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole blood | Refrigerated (preferred) | 8 days | |
| Ambient | 8 days |
Reject Due To
| Hemolysis | NA |
| Lipemia | NA |
| Icteric | NA |
| Other | NA |
Clinical Information
The PAI-1 4G allele is an inherited characteristic. If the polymorphism is present in a heterozygous or homozygous fashion, we recommend that the patient and their family consider genetic counseling to obtain additional information on inheritance and to identify other family members at risk.
If a patient possesses two or more congenital or acquired risk factors, the risk of disease may rise to more than the sum of the risk ratios for the individual risk factors. For instance, a combination of the 4G/4G genotype and the insulin resistance syndrome may confer an increase in cardiovascular disease risk over that conferred by the presence of an isolated PAI-1 4G/4G polymorphism.
Cautions
Genetic testing by PCR provides exceptionally high sensitivity and specificity. Incorrect genotyping results can be caused by rare polymorphisms in primer binding sites and to misidentification of specimens by collectors or laboratory personnel. This assay analyzes only the PAI 4G/5G locus and does not measure genetic abnormalities elsewhere in the genome.
Method Description
Patient DNA was evaluated for the PAI-1 4G/5G promoter polymorphism, which is a single base pair guanine (4G/5G) deletion/insertion polymorphism, using polymerase chain reaction (PCR) technology and restriction fragment length polymorphism (RFLP).
Day(s) Performed
Wednesday, Saturday
Report Available
7-14 daysPerforming Laboratory
Esoterix CoagulationTest Classification
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.CPT Code Information
81400
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FPAIG | PAI-1 Gene Polymorphism | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z4765 | PAI-1 Locus 4G/5G Polymorphism | Not Provided |
| Z4766 | Results | 52757-2 |
| Z4767 | Interpretation | Not Provided |
| Z4768 | Comments | 77202-0 |
Forms
New York Clients - Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing is available in Special Instructions.