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Test Code LABFPALI Paliperidone, Serum

Additional Codes

Test Name in EPIC EPIC Test Code Mnemonic Mayo Test ID
PALIPERIDONE, SERUM LABFPALI FPALI FPALI

 


Specimen Required


***Must submit one specimen per order. Specimens cannot be shared between multiple orders.***

Specimen Type: Serum

Collection Container/Tube: Red

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Draw blood in a plain, red-top tube(s). (Serum gel tube is not acceptable.) Spin down and send 1 mL of serum refrigerate in a preservative-free plastic vial.


Method Name

High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Paliperidone, Serum

Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen 

Reject Due To

Other Polymer gel separation tube (SST or PST)

Reference Values

None Detected ng/mL

 

Units: ng/mL

Interpretation

Paliperidone is an atypically-structured antipsychotic agent and the main pharmacologically active metabolite of Risperidone (commonly referred to as 9-hydroxyrisperidone).

 

The following mean plasma paliperidone concentrations have been reported:

3 mg single extended release oral dose: 4.9 ng/mL at 24 hours

 

6 mg single extended release oral dose: 10 ng/mL at 24 hours

 

12 mg single extended release oral dose: 20 ng/mL at 24 hours

 

3 mg extended release oral dose for 7 days: 11 ng/mL at 22 hours after last dose

 

78-156 mg IM once monthly for 6 months: 10-20 ng/mL (median trough concentration)

 

Acute ingestion of 180 and 504 mg extended release paliperidone resulted in serum concentrations of 170 and 883 ng/mL, respectively, approximately 40 hours after ingestion and the reported serum concentration following acute ingestion of 270 mg was 100 ng/mL 16 hours post-ingestion.

 

A femoral blood paliperidone concentration of 240 ng/mL was the only finding in an individual who died 2 weeks after a 525 depot IM injection.

 

The blood/plasma ratio of paliperidone is 0.7-0.8.

Day(s) Performed

Monday - Sunday

Report Available

8 to 10 days

Performing Laboratory

NMS Labs
Essentia Health Laboratories Note:

NMS Test Code:  4113SP

CPT Code Information

80342

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FPALI Paliperidone, Serum 9383-1

 

Result ID Test Result Name Result LOINC Value
Z3528 Paliperidone 9383-1

Test Classification

This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration.