Test Code LABHEPXA Heparin Anti-Xa Assay
Additional Codes
Test Name in EPIC | EPIC Test Code | Mnemonic |
---|---|---|
HEPARIN ANTI-XA ASSAY | LABHEPXA | HEPXA |
Methodology
Chromogenic Assay
Specimen Requirements
Specimens must be centrifuged and plasma separated from cells within 1 hour of collection.
Specimen Type: Platelet-poor plasma
Container/Tube:
Fill Blue top tube to the etched line located just below the cap of the tube.
Preferred: Full Light-blue top (3.2% sodium citrate)
Acceptable: Full Sodium citrate (BD® or Greiner tubes)
Specimen Volume: 1 mL
Specimen Minimum Volume: 0.5 mL
Collection Instructions:
1. Draw level 6 hr after start of infusion and then 6 hours after each change.
2. Unacceptable specimens: Specimens that are short-draws, over-draws, clotted or hemolyzed may yield incorrect results.
3. If sending from a site spin down, remove top 2/3 of plasma, and spin plasma again in a polyproyplene (cloudy plastic) vial.
4. Aliquot top 3/4 and place platelet-poor plasma in a polypropylene (cloudy plastic) vial.
5. Glass vials are not acceptable for processing/transport/storage.
Additional Information:
1. Double-centrifuged specimens are critical for accurate results as platelet contamination may cause spurious results.
2. If there is a delay in transport of >2 hours, send specimen frozen.
3. To monitor Enoxaparin (Lovenox) therapy, draw for peak 4-6 hours post dose.
Specimen Transport Temperature
Frozen OK/Ambient 2 hours OK/Refrigerate NO
Day(s) Test Set Up
Monday through Sunday (all shifts)
Performing Laboratory
Coagulation-
Deer River Hospital Lab, Northern Pines Lab, Sandstone Hospital Lab, SMDC Clinical Lab, St. Joseph's Medical Center Lab, St. Mary's Hospital - Superior Lab, Virginia Hospital Lab
Ada Hospital Lab, Fargo Hospital Lab, Fosston Hospital Lab, Holy Trinity Hospital Lab, St. Mary's - Detroit Lakes Hospital Lab
Test Classification and CPT Coding
85520
Reference Values
Therapeutic Ranges:
Range: IU/mL
Comments: This test is not validated for other direct Xa inhibitor drugs (e.g. Rivaroxaban, Apixaban, etc.)
*Unfractionated Heparin:
Therapeutic range may vary from 0.2 to 0.7 IU/mL. The upper and lower limit of therapeutic range varies based on intensity (indication), see dosing nomogram.
*Low Molecular Weight Heparin:
Enoxaprin (Lovenox): 0.6 to 1.0 IU/mL (for 1mg/kg twice daily dosing), 1 to 2 IU/mL (for 1.5 mg/kg once daily dosing)
**Other LMWH products may yield different therapeutic ranges. Please consult drug product insert for appropriate range.