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Test Code O219658 First Dose Daratumamab(Darzalex)/ Isatuximab(Sarclisa) Panel

Important Note

First Dose Daratumamab(Darzalex)/ Isatuximab(Sarclisa)Panel #O219658

Labs must be ordered for the first time the medication (baseline) is given to the patient.

Tests included in O219658

Type and Screen - Baseline Lab. Before first Darzalex/Sarclisa infusion

Direct Coombs - Baseline Lab. Before first Darzalex/Sarclisa infusion

BB Special Ag (LAB8209) - Baseline Lab. Before first Darzalex/Sarclisa infusion

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Additional Codes

Test Name in EPIC EPIC Test Code
First Dose Daratumamab(Darzalex)/ Isatuximab(Sarclisa) O219658

 

Test Alias

Dara, Isatuximab, Daratumumab, Darzalex,  Isatuximab, Sarclisa

Useful For/Utility

Required for patients about to receive their first dose of Daratumumab or Sarclisa drugs for multiple myeloma treatment. MUST BE PERFORMED PRIOR TO BEGINNING TREATMENT. Includes: Type and Screen, DAT and BBSAG

Daratumamab(Darzalex)/ Isatuximab(Sarclisa) Order Set – included to order genotype or phenotype, whichever is indicated by testing results.

Methodology

Manual

Clinical Information

Daratumumab is an IgG monoclonal antibody that recognizes CD38 on myeloma cells and on red blood cells. Sarclisa binds CD38 on RBCs. Both drugs present as a passively acquired IgG antibody that will react with all reagent red cells at the IAT phase of testing. Interference from these drugs can last up to six months after therapy has stopped.

Specimen Requirements

Specimen Type: Whole blood

Container/Tube: Pink top (K2EDTA)-Lavender top (EDTA) is also acceptable.

Specimen Volume: 6 mL

Specimen Minimum Volume: 4 mL

Collection Instructions: Send specimen in original VACUTAINER.
Additional Information:

1. Antigen type needed is required. Common  antigen types include: c antigen, C antigen, e antigen, E antigen, Kell antigen, Fya antigen, Fyb antigen, Jka antigen, and Jkb antigen.

2. Label specimen appropriately (K2EDTA or EDTA blood).

Specimen Transport Temperature

Ambient/Refrigerate OK/Frozen NO

Day(s) Test Set Up

Upon request

Performing Laboratory

Essentia Health Laboratory-Transfusion Services

St. Joseph's Medical Center Lab, Sandstone Hospital Lab, SMDC Clinical Lab, St. Mary's Hospital - Superior Lab, Virginia Hospital Lab, Deer River Hospital Lab, Northern Pines Hospital Lab, Moose Lake Hospital Lab, Ada Hospital Lab, Fargo Hospital Lab, Fosston Hospital Lab, St. Mary's - Detroit Lakes Hospital Lab, Holy Trinity Hospital Lab

Test Classification and CPT Coding

86905

Test Algorithm

Failure to request this orderset prior to the first dose of either drug will likely cause transfusion delays, if transfusion is indicated in course of treatment.  Due to the nature of interference with our reagent red cells, the work up may need to be sent out to a larger reference lab for DTT/AET screening cells.